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肝细胞肝癌中p15基因产物的表达及其意义 被引量：3

Expression and significance of p15 gene in the human hepatocellular carcinoma
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摘要 用免疫组织化学方法 (SABC法 )检测p15基因在 5 3例肝细胞肝癌 (HCC )标本中的表达。p15基因阳性表达率为 64 .2 % ( 3 4/5 3 )。病理I ,II级p15阳性率明显高于III级 (均为P <0 .0 5 ) ;临床分期T1 ,T2 期p15阳性率均明显高于T3期 (均为P <0 .0 5 )与T4 期 (均为P <0 .0 1)。提示p15基因的异常表达在HCC的发生、发展中可能起重要作用 ;p15基因表达可以作为病程、预后判断的候选检测指标 ,对HCC的基因治疗有潜在的价值和意义。
作者 王英 崔忠 李开宗 李玉松 秦亚东 王文勇 王剑波
机构地区 解放军第四六七医院外一科 解放军白求恩国际和平医院肝胆外科 第四军医大学
出处 《中国普通外科杂志》 CAS CSCD 2004年第7期540-542,共3页 China Journal of General Surgery
关键词 肝细胞癌 病理学 肝肿瘤 病理学 基因P15
分类号 R735.7 [医药卫生—肿瘤] R730.261 [医药卫生—肿瘤]
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参考文献14

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同被引文献38

  • 1邓伟,梁力建.血管生成素和VEGF在人肝细胞癌血管生成作用机制的研究[J].中国普通外科杂志,2005,14(6):436-440. 被引量：9
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中国普通外科杂志
2004年 第7期

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