摘要
目的 :探讨格列卫 (STI 5 71)术前用于胃肠间质瘤 (GIST)的新辅助治疗。方法 :晚期GIST 1例 ,剖腹探查未能够手术切除 ,采用格列卫 (40 0mg/日 )新辅助治疗 ,通过CT、再次手术所见和术后病理组织检查评价其疗效。结果 :经过格列卫治疗后 ,盆腔GIST肿块由 13 0cm× 10 0cm× 10 0cm缩小为 10 0cm× 9 0cm× 9 0cm ,即瘤体缩小了 38% ;再次进行手术获得成功 ,病理组织学检查可见肿瘤组织发生大片状坏死 ;未见明显毒副反应。术后随访 13个月 ,患者一般情况良好 ,仍然无病生存。结论 :格列卫可以用于GIST的新辅助治疗 ,能够使肿瘤降期 ,便于完整切除。
Objective:To investigate the efficacy of a neoadjuvant therapy of GIST with gelivec TM (STI 571).Methods:A patient with advanced GIST whose tumor couldnt be excised was treated with a neoadjuvant therapy-gelivec TM (400 mg/day). The therapeutic efficacy was evaluated through CT, the find of second operation and histopathologic examination.Results:After treated with gelivec TM, the tumor in pelvic cavity diminished from 13.0 cm×10.0 cm×10.0 cm to 10.0 cm×9.0 cm×9.0 cm. The volume of tumor decreased by 38%. The tumor was resected the tumor tissue occurred mass of necrosis under the hitopathologic examination The tumor was resected ,and the patient didnt show any toxicity. After 13 months of post-operation follow-up, the patient is still disease-free survivaly.Conclusion:Gelivec TM can be used for GIST as a neoadjuvant therapy. It can lower the stage of tumors and easy to be resected completely.
出处
《临床肿瘤学杂志》
CAS
2004年第3期244-246,共3页
Chinese Clinical Oncology