格列卫新辅助治疗胃肠间质瘤

Neoadjuvant Therapy of GIST with GelivecTM

目的 :探讨格列卫 (STI 5 71)术前用于胃肠间质瘤 (GIST)的新辅助治疗。方法 :晚期GIST 1例 ,剖腹探查未能够手术切除 ,采用格列卫 (40 0mg/日 )新辅助治疗 ,通过CT、再次手术所见和术后病理组织检查评价其疗效。结果 :经过格列卫治疗后 ,盆腔GIST肿块由 13 0cm× 10 0cm× 10 0cm缩小为 10 0cm× 9 0cm× 9 0cm ,即瘤体缩小了 38% ;再次进行手术获得成功 ,病理组织学检查可见肿瘤组织发生大片状坏死 ;未见明显毒副反应。术后随访 13个月 ,患者一般情况良好 ,仍然无病生存。结论 :格列卫可以用于GIST的新辅助治疗 ,能够使肿瘤降期 ,便于完整切除。

Objective:To investigate the efficacy of a neoadjuvant therapy of GIST with gelivec TM (STI 571).Methods:A patient with advanced GIST whose tumor couldnt be excised was treated with a neoadjuvant therapy-gelivec TM (400 mg/day). The therapeutic efficacy was evaluated through CT, the find of second operation and histopathologic examination.Results:After treated with gelivec TM, the tumor in pelvic cavity diminished from 13.0 cm×10.0 cm×10.0 cm to 10.0 cm×9.0 cm×9.0 cm. The volume of tumor decreased by 38%. The tumor was resected the tumor tissue occurred mass of necrosis under the hitopathologic examination The tumor was resected ,and the patient didnt show any toxicity. After 13 months of post-operation follow-up, the patient is still disease-free survivaly.Conclusion:Gelivec TM can be used for GIST as a neoadjuvant therapy. It can lower the stage of tumors and easy to be resected completely.