双诺希胶囊对实验性高脂血症大鼠血脂水平的影响

Effect of Shuangnuoxi Capsule on Blood Lipid in Experimental Hyperlipidemia rats

目的观察双诺希(SHNX)胶囊对高脂血症大鼠血脂的影响。方法用高脂饲料喂饲大鼠建立高脂血症模型,随机将其分为正常对照组、高脂模型组、安妥明组、SHNX大剂量组、SHNX中剂量组和SHNX小剂量组6组,连续喂饲并灌胃给药1个月后,观察SHNX对高脂血症大鼠血脂水平的影响。结果SHNX能明显降低血清总胆固醇(TC)、血清甘油三酯(TG)含量,也能明显提高血清高密度脂蛋白亚组分胆固醇(HDL2-C)及高密度脂蛋白胆固醇(HDL-C)的含量。结论用SHNX治疗血脂紊乱大鼠有明显的效果。

Objective To observe the effect of Shuangnuoxi capsule(SHNX) on blood lipid in ratssuffering from hyperlipidemia. Methods 60 hyperlipidemia models rats were divided randomly into Fivehyperlipidemia models of rats establisthed with high fat feed and control group,The levels of bloodlipid in rats were observed after being given different dosages of SHNX 1.600, 0.800, 0.400 g/kg, andclofibrate 0.250 g/kg for 1 month.Results The levels of serumcholesterol(TC), serumtriglyceride(TG)obviously decreased, remarkably increased the levels of high density lipoprotern subgroup 2-cholesterol(HDL2-C) and high density lipoprotein cholesterol in SHNX groups. Conclusion SHNX has a markedtherapeutic effect on dislipidemia in rats by modulating blood lipid.