血清肌钙蛋白Ⅰ对急性病毒性心肌炎患儿的临床意义

Clinical Significance of Serum Troponin Ⅰin Child with Acute Viral Myocarditis

目的观察急性病毒性心肌炎(VMC)患儿血清肌钙蛋白Ⅰ(cTnⅠ)水平变化,探讨cTnⅠ对VMC的诊断价值。方法选择符合VMC诊断标准的首诊VMC患儿52例,用ELISA法测定治疗后前4周内血清cTnⅠ的浓度。25例健康志愿者为对照组。结果52例患儿定量测定cTnⅠ浓度(10.57±4.89μg/L)显著高于正常对照组(1.94±0.84μg/L)(P<0.01);治疗的前第1周内最高(10.57±4.89)μg/L,治疗2周后开始下降为8.45±3.93μg/L,第4周基本恢复正常(2.05±0.91μg/L);ECG单项异常与ECG重叠异常的患儿血清cTnⅠ的浓度(13.03±4.98;15.57±5.34)明显较ECG无异常患儿(6.78±2.97)高。结论检测VMC患儿血清cTnⅠ水平,可以作为VMC的明确诊断、判断病情进展和评估预后的依据。

Objective To observe the alteration of serum troponin Ⅰ(cTn Ⅰ) in child with acuteviral myocarditis(VMC) ,and to assess the diagnostic values of cTn Ⅰin acute viral myocarditis.Methods cTn Ⅰwas detected in 52 child with VMC and compared with 25 healthy volunteers(controlsubjects) . Results The level of cTnⅠin 52 child with VMC were significantly higher than control group( P< 0. 01). The level of cTnⅠ in ECG normal group were significantly lower than one abnormal ECG groupand two or more abnormal ECG group(6.78 ±2.9, vs13.03 ±4.98 , 15.57 ±5.34.P< 0. 01). The level ofcTnⅠwere highest in first week ,began to decrease in second ,and recovered normal level almost 4st week.Conclusion Troponin Ⅰis a sensitive and specific marker in the patients with VMC. It can be helpfulin t diagnosis of myocardial injury. Quantitation detection of cTn Ⅰcan evaluate the progress of VMC.