纳洛酮治疗肝性脑病

Clinical Research of Naloxone on Cirrhotic Patients with Hepatic Encephalopathy

目的观察纳洛酮治疗肝硬化合并肝性脑病的疗效。方法肝硬化合并肝性脑病89例,随机分成2组,治疗组45例,对照组44例;对照组给予常规治疗,治疗组在常规治疗的基础上,加用纳洛酮,治疗前后测定血氨和血浆内啡肽(β-EP)水平。结果治疗组显效26例,有效11例,总有效率为82.2%;对照组显效13例,有效14例,总有效率为61.4%,两组在显效例数以及总有效率有显著性差异(p<0.05);两组病人治疗后血氨均明显下降,治疗后两组血氨比较,无显著性差异(P>0.05);两组病人治疗后血浆β-EP均下降,但治疗组下降更显著(P<0.05)。结论纳洛酮治疗肝硬化并发肝性脑病疗效确切。

Objective To observe the clinical effects of naloxone on cirrhotic patients withhepatic encephalopathe [ HE] .Method Eighty-night cases of cirrhotic patients with HE were randomlydivided into two groups.The patients of control group(44 cases)just received routine treatment. Intreatment group , the patient were added naloxone at the base of routine treatment. Ammonia and endorphinin plasm were detected pre -and post-treatment. Result There was significant difference in theexcellent effective rate and the total effective rate between the two groups( P< 0.05) .Blood ammoniadecreased significantly in two groups after treatment of naloxone without difference between the twogroups. Compared with control group, endotphin in plasm was lower after treayment.Conclusion Nalox-one is effective in the treatment of HE.