胆囊切除术与幽门螺杆菌感染关系的研究

Study of Relationship Between Cholecystectomy and Helicobacter Pylori Infection

目的 探讨胆囊切除术与幽门螺杆菌感染的关系。方法 研究组为胆囊结石胆囊炎患者 111例 ,与研究组相匹配的有上消化道症状而无胆囊结石的患者 5 77例作为对照组 ,所有患者均行13 C呼气试验 ,以检查胃内活动性幽门螺杆菌 (Hp)感染 ,比较胆囊结石组和对照组人群Hp感染率。胆囊结石组中Hp阳性患者术后均行一疗程根治Hp治疗 ,随访 3～ 6个月。结果 胆囊结石组Hp感染率为 4 5 .9% ,对照组Hp感染率为 2 7.4 % ,前者明显高于后者 (P<0 .0 1) ;胆囊切除术后Hp阳性患者根治Hp治疗后随访 3～ 6个月 ,均未见明显的上腹部隐痛、饱胀不适等症状。结论 胆囊结石胆囊炎患者Hp感染率较高 ,Hp可能是引起“胆囊切除术后综合征”的因素之一 。

Objective To study there lationship between cholecystectomy and Helicobacterpylori (Hp) infection . Methods One hundred and elevenpatients with cholecys to lithiasis were chosenastheinvestigationgroup ,while 5 77 patients with upper digestivetractsymptoms without cholecys to lithiasis as the control group .All the patients took the13 C breath test to determinewhe ther they were infectedbyHp .All the patients with Hpinfection continuederadicaltherapy for Hpinfection for one course after cholecystec to my and were follo weduponout patientbasis.Results The infection ratein the investigation group was 4 5 .9% ,while 2 7.4 % in the control group .During the 3to 6months of follow upfor thepatientsundergoingeradicaltherapyforHpinfection ,we found no patient complaining of epigastricpain ,malaise, belching and nausea.Conclusion The infectionrate of Hpinpatients with cholecys to lithiasisi shigh ,Hpmay be one of the factor scausing“post cholecy stectomy syndrome” .Eradical therapy for Hp after cholecystectomy will help improve thee ffects of operation .