乳腺癌pS2、neu癌基因表达与淋巴结转移的关系

Relationship between the expression of pS2 and neu oncogene in breast carcinomas and metastases of drainage lymph nodes

目的 :探讨女性乳腺癌pS2、neu的表达及其意义。方法 :应用免疫组化SP法对 6 5例乳腺癌组织蜡块进行回顾性检测。结果 :在 6 5例乳腺癌中 ,pS2阳性表达率为 5 0 .8% ;neu阳性率为 4 6 .2 % ,且淋巴结转移组和未转移组间差异有显著性 (P <0 .0 1)。结论 :neu基因蛋白的过表达与淋巴结转移关系密切 ,检测neu表达情况可以作为判断乳腺癌患者预后的重要参考指标之一。

Objective:To study the expression of pS2 and neu oncogene in female breast carcinomas and its significance.Methods: Immunohistochemistry SP method was used to detect the oncogene expression retrospectively in tissue blocks of 65 cases of breast cancer.Results:The positive expression of pS2 and neu are 50.8% and 46.2%,respectively,in 65 cases of breast cancer.The positive rates of neu oncogene in lymph node metastasis were markedly different from that without metastasis(P<0.01) .Conclusions:The overexpression of neu oncogene correlates with lymph node metastasis intimately.Therefore,clinic investigation of the expression neu may be one of important reference indexes to predict prognosis in patients.