硝酸甘油治疗小儿难治性心力衰竭68例临床分析

Refractory heart failure in children:A report 68 cases

目的 :观察硝酸甘油治疗小儿难治性心力衰竭的疗效。方法 :6 8例难治性心力衰竭患儿随机分成两组 ,在常规强心、利尿的基础上 ,治疗组加用硝酸甘油治疗 ,对照组加用酚妥拉明治疗 ;观察两组治愈率及气促、肺部罗音的消失情况。结果 :治疗组治愈率 92 .5 %高于对照组 71.4 % (P <0 .0 5 )。气促缓解天数治疗组 (4 .5 2± 1.2 3)天少于对照组 (6 .18± 1.36 )天 (P <0 .0 1) ;肺部罗音消失天数治疗组 (5 .2 4± 1.18)天少于对照组 (6 .6 7± 1.34)天 (P <0 .0 1)。结论 :硝酸甘油是治疗小儿难治性心力衰竭的有效药物。

Objective:To investigate the effect of Refractory heart failure in children.Methods:Sixty-eight cases of refractory heart failure in children were randomly divided into two groups.The cure group were given nitroglycerin and the control group were given phentolamine,in addition to the usual administration and the progress of the disease was observed.Results:The effective rate was (92.5)% and 71.4% in the cure group and the control group,respectively.The difference between the two groups was remarkable(P<0.05).Mitigate duration of dyspnea was (4.52±1.23)days and (6.18±1.36)days in the cure group and the control group,respectively(P<0.01).Disappear duration of rales was (5.24±1.18)days and (6.67±1.34)days in the cure group and the control group,respectively(P<0.01).Conclusions:Nitroglycerin is an effective drug for treatment of refractory heart failure.