多发性骨髓瘤患者血清脂质代谢变化及其临床意义

Change of serum lipid metabolism in patients with multiple myeloma and its clinical significance

目的 :探讨多发性骨髓瘤 (MM)患者血清总胆固醇等脂质变化及其临床意义。方法 :测定 4 8例MM患者在治疗前和治疗后的血清总胆固醇 (TC)、甘油三酯 (TG)、高密度脂蛋白胆固醇 (HDL C)及与脂质代谢相关的生物化学指标 ,并对血清胆固醇与血浆蛋白变化作相关分析。结果 :MM患者治疗前TC和HDL C比正常人群明显偏低 (P <0 .0 0 1) ,且TC水平与血浆总蛋白 (TP)呈负相关 (P <0 .0 1) ,与血清白蛋白 (Alb)呈正相关 (P <0 .0 1)。经MP治疗 2个月后 ,好转患者血清脂质水平均有不同程度改善 ,其中TC和HDL C改善显著 (P <0 .0 0 1)。结论 :血清总胆固醇可以作为多发性骨髓瘤患者实验辅助诊断和临床疗效观察有用的生物化学指标。

Objective:To investigate the change of biochemical index of blood lipid profiles such as serum total cholesterol levels in patients with multiple myeloma(MM) and its clinical significance.Methods:The serum total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol (HDL-C),and other biochemistry markers correlated with lipid metabolism were determined at the time of diagnosis and two months later in 48 patients with MM.The relativity analysis was made between serum TC and plasma albumen.Results:The untreated MM had reduced TC(P<0.001) and HDL-C(P<0.001) levels compared with the healthy.There were negative correlations between serum TC levels and plasma total protein(TP) levels(P<0.001),while there were positive correlations between TC levels and albumin(Alb) levels(P<0.01) in all untreated MM.Two months after treatment,the blood lipid levels improved in all patients with MM,while a notabile increase of serum TC and HDL-C levels(P<0.001) was observed in all the patients responding to the therapy.Conclusions:The serum total cholesterol might be considered a useful biochemical and prognostic index in experimental diagnosis and estimating the clinical effect for patients with MM.