基质金属蛋白酶(MMP-2、MMP-9)在人脑星形胶质细胞瘤的表达

Expression of matrix metalloproteinases(MMP-2、MMP-9)in human astrocytoma

目的 探讨基质金属蛋白酶(matrix metalloproteinases,MMP)与人脑星形胶质细胞瘤浸润性生长之间的关系,以及基质金属蛋白酶的阳性表达与星形胶质细胞瘤病理分级的关系。方法 应用免疫组织化学染色法(SP法)检测44例人脑星形胶质细胞瘤组织中MMP-2、MMP-9的表达。结果 Ⅲ、Ⅳ级中MMP-2、MMP-9蛋白的表达显著高于Ⅰ、Ⅱ级,而正常脑组织中无表达;在人脑星形胶质细胞瘤中MMP-2和MMP-9的表达之间无明显相关性。结论 MMP-2、MMP-9的表达与星形胶质细胞瘤的恶性程度有关,其高表达可能与星形胶质细胞瘤的侵袭转移有关。

Objective To study the relationship between matrix metalloproteinases (MMPs) and the infiltrative growth of human astrocytoma as well as between the expression of MMPs in human astrocytoma and the pathological grading of malignancy. Methods Expressions of MMPs (MMP-2,MMP-9) were detected in 44 cases of astrocytoma by means of immunohistochemical staining. Results The expressions of MMP-2 and MMP-9 in Grade Ⅲ, Ⅳ astrocytoma were significantly higher than those in Grade Ⅰ , Ⅱ astrocytoma ,and the expressions of MMP-2 and MMP-9 in normal brain were negative. No significant correlation was found between the expression of MMP-2 and MMP-9 in human astrocytoma. Conclusion The expressions of MMP-2 andMMP-9 are positively correlated with the pathologic grading of astrocytoma. The higher expressions of MMP-2 and MMP-9 in human brain astrocytoma may be associated with the invasion and metastasis of astrocytoma.