西红花酸对大鼠实验性动脉粥样硬化的影响(英文)

Effects of crocetin on experimental atherosclerosis in rats

目的 研究西红花酸对大鼠实验性动脉粥样硬化的影响。方法 采用给予大剂量维生素 D2 ( VD2 )后饲喂高胆固醇饲料诱发大鼠实验性动脉粥样硬化模型 ,测定大鼠血清总胆固醇 ( TC)、甘油三酯 ( TG)、低密度脂蛋白( L DL- C)、高密度脂蛋白 ( HDL- C)、丙二醛 ( MDA)含量和超氧化物歧化酶 ( SOD)活性。取主动脉和肝脏做病理切片检查。结果 高、低剂量的西红花酸能显著降低动脉粥样硬化大鼠血清 TC、L DL - C和 MDA含量 ;显著升高血清 HDL- C含量、SOD活性和抗动脉粥样硬化指数 ( AAI)。病理切片结果表明 ,西红花酸能明显减轻模型大鼠动脉粥样硬化性损伤。结论 西红花酸具有显著的抗大鼠实验性动脉粥样硬化作用。

Object To study the effect of crocetin (CCT) on experimental atherosclerotic formation in rats. Methods Atherosclerotic rat models were replicated by administration of excessive vitamin D 2 (VD 2) followed by feeding a high-cholesterol diet. The blood samples were assayed for the content of TC, TG, LDL-C, HDL-C, MDA level, and the activity of SOD in serum. The sections of aortia and liver were examined. Results High-and low-dosages of CCT were found significantly to reduce serum TC, LDL-C, and MDA level; and elevate serum HDL-C level, SOD activity, and antiatherosclerotic index (AAI) in atherosclerotic rats. The histopathological observation of aortic arch showed the alleviation of atherosclerotic damage by CCT. Conclusion CCT has obvious antiatherosclerotic effect in rats.