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治疗乙肝病毒新药——阿地福韦酯 被引量：1

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摘要 阿地福韦(adefovir)为嘌呤类衍生物,是新型的开链核苷酸类广谱抗病毒药物.在人体中口服生物利用度＜5%.Gilead Sciences公司研制开发出了阿地福韦的前体--阿地福韦酯(adefovir dipivoxil)的口服片剂和胶囊剂,口服生物利用度可达40%以上.阿地福韦酯胶囊的商品名为Hepsera,美国FDA 2002年11月批准其用于乙型肝炎的治疗.
作者 金慧萍 李中东 焦正
机构地区 复旦大学附属华山医院临床药学研究室
出处 《中国临床药学杂志》 CAS 2004年第4期245-246,共2页 Chinese Journal of Clinical Pharmacy
关键词 药物治疗 乙肝 阿地福韦酯 抗病毒药物
分类号 R978.7 [医药卫生—药品] R512.62 [医药卫生—内科学]
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参考文献11

  • 1成军.阿地福韦在慢性乙型肝炎治疗中的应用[J].国外医学（病毒学分册）,2001,8(3):85-91. 被引量：9
  • 2Buti M, Esteban R. Adefovir dipivoxil [J]. Drugs Today(Barc), 2003,39(2):127.
  • 3Gilson R J, Chopra KB, Newell AM, et al. A placebo-controlled phase study of adefovir dipivoxil in patients ,with chronic hepatitis B virus infection[J]. Viral Hepat, 1999,6(5) :387.
  • 4Justin D. Adefovir dipivoxil 10 mg for the treatment of chronic Hepatitis B[EB/OL]. Http://www. Fda. Gov/ohrms/dockes, 2002-08-14/2003-07-10.
  • 5Cundy KC. Clincal Pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir[J]. Clin Pharmacokinet, 1999,36(2): 127.
  • 6Marcellin P, Chang TT, Lim SG, et al. Adefovir Dipivoxil 437 Study Group. Adefovir dipivoxil for the treatment of hepatitis B eantigenpositive chronic hepatitis B[J]. N Engl J Med,2003,348(9) :808.
  • 7Marcellin P. Advances in therapy for chronic hepatitis B[J]. Semin Liver Dis,2002,22(1):33.
  • 8Tillmann HL, Bock CT, Bleck JS, et al. Successful treatment of fibrosing cholestatic hepatitis using adefovir dipivoxil in a patient with cirrhosis and renal insufficiency[J]. Liver Transpl,2003,9(2): 191.
  • 9Perrillo R, Schiff E, Yoshida E, et al. Adefovir dipivoxil for the treatment of lamivudine-resistent hepatitis B mutants[J]. Hepatology, 2000,32(1):129.
  • 10Yang H, Fry J, Brossgart C, et al. Resistance surveillance in chronic hepatitis B patients treated with adefovir dipivoxil for up to 60 weeks[J].Hepatology, 2002,36(2) :464.

二级参考文献29

  • 1[1]Heatheote EJ,Jeffers L,Wright T,et al.Loss of serum HBV DNA and HBeAg and seroconversion following short-term (12 weeks) adefovir dipivoxil therapy in chronic hepatitis B:two placebo-controlled phase Ⅱ studies(abstr).Hepatology,1998,28(4):317A
  • 2[2]Schakm SW,Wolters L,van Nunen,et al.New nucleoside analogues for chronic hepatitis B.Acta Gastro-enterologica Belgica,2000,63(2):191-193
  • 3[3]http://www.docguide.com
  • 4[4]Lo CM,Cheung ST,Lai CL,et al.Liver transplantation in Asian patients with chronic hepatitis B using lamivudine prophylaxis.Ann Surg,2001,233 (2):276～ 281
  • 5[5]Perrillo R,Schiff E,Yoshida E,et al.Adefovir dipivoxil for the treatment of lamivudine-resistent hepatitis B mutants.Hepatology,2000,32 (1):129 ～ 134
  • 6[6]Cullen JM,Li DH,Brown C,et al.Antiviral efficacy and pharmacokinetics of oral adefovir dipivoxil in chronically woodchuck hepatitis virus-infected woodchucks.Antimicrob Agents Chemother,2001,45(10):2740～2745
  • 7[7]Walsh KM,Woodall T,Lamy P,et al.Successful treatment with adefovir dipivoxil in a patient with fibrosing cholestatic hepatitis and lamivudine resistant hepatitis B virus.Gut,2001,49(3):436～440
  • 8[8]Benhammou Y,Bochet M,Thibault V,et al.Safety and efficacy of adefovir dipivoxil in patients coinfected with HIV-1and lamivudine resistant hepatitis B virus:an open-label pilot study.Lancet,2001,358(9283):718～723
  • 9[9]Regev A,Schiff ER.Drug therapy for hepatitis B.Adv Intern Med.2001,46:107～ 35
  • 10[10]Delaney WE 4th,Locarnini S,Shaw T.Resistance of hepatitis B virus to antiviral drugs:current aspects and directions for future investigation.Antivir Chem Chemother.2001,12(1):1 ～35

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中国临床药学杂志
2004年 第4期

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