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过氧化氢酶高表达抑制活性氧诱导的人晶状体上皮细胞凋亡 被引量：3

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摘要 晶状体上皮细胞 (lens epithelial cell, LEC) 凋亡是除先天性白内障外各种类型白内障发生的共同分子机制[1],活性氧损伤是LEC凋亡的主要原因[2].
作者 李立梅 刘戈飞 吴恩梅 张劲松
机构地区 中国医科大学附属第一医院眼科 中国医科大学卫生部细胞生物学重点实验室 沈阳市皇姑区医院五官科
出处 《中华眼科杂志》 CAS CSCD 北大核心 2004年第7期478-479,共2页 Chinese Journal of Ophthalmology
关键词 过氧化氢酶 活性氧 晶状体上皮细胞 细胞凋亡 白内障
分类号 R776.1 [医药卫生—眼科]
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参考文献6

  • 1Li WC, Kuszak JR, Dunn K,et al. Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals. J Cell Biol, 1995, 130: 169-181.
  • 2Spector A. Oxidative stress-induced cataract: mechanism of action. FASEB J, 1995, 9: 1173-1182.
  • 3Green DR, Reed JC. Mitochondria and apoptosis. Science, 1998, 281: 1309-1312.
  • 4Liu X, Kim CN, Yang J, et al. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell,1996, 86: 147-157.
  • 5Chen Q, Gong B, Almasan A. Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis. Cell Death Differ, 2000, 7: 227
  • 6Finkel T. Oxidant signals and oxidative stress. Curr Opin Cell Biol,2003, 15: 247-254.

同被引文献21

  • 1Spector A. Oxidative stress-induced cataract: mechanism of action.FASEB J, 1995, 9( 12): 1173-1182.
  • 2Sanderson J, McLauchlan WR, Williamson G. Quercetin inhibits hydrogen peroxide-induced oxidation of the rat lens. Free Radic Biol Med, 1999, 26(5-6): 639-645.
  • 3Chen Q, Gong B, Almasan A. Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis. Cell Death Differ, 2000, 7(2): 227-233.
  • 4Giblin FJ. Glutathione: a vital lens antioxidant. J Ocul Pharmacol Ther, 2000, 16 (2): 121-135.
  • 5Yildirim Z, Yildirim F, Ucgun NI, et al. The evaluation of tile oxidative stress parameters in nondiabetie and diabetic senile cataract patients[ J]. Biol Trace Elem Res,2009,128:135-143.
  • 6Zhang M,Shoeh M, Liu P, et al. Topical metal chelation Iherapy ameliorates oxidation-induced toxicity in diabetic calaract [ J ]. J Toxicol Environ Health A ,2011,74:380-391.
  • 7Nakata R,Takahashi S, Inoue H. Recenl advances in the study an resveratrol [ J ]. Biol Pizarro Bull, 2012,35 : 273-279.
  • 8Davies M, Roulleau J. Statement uf retraction. Cardioprutective effect of resveratrol via HO-I expression involves p38 map kinase and PI-3-kinase signaling, but does not involve NFkB[ J]. Free Radio Res,2012,46:359.
  • 9Ye P, Lin K, Li Z, et al. [ (-)-Epigalh)catechin gallate regulates expression of apoptotic genes and protects cultured human lens epithelial cells under hyperglycemia] [ J]. Mol Biol ( Mosk ), 2013,47:251-257.
  • 10Raju l,Kannan K,Abraham EC. FoxO3a Serves as a Biomarker of Oxidative Stress in Human Iens Epithelial Ceils under Conditions of Hyperglycemia [ J ]. PIxS One,2013,8 : e67126.

引证文献3

二级引证文献2

中华眼科杂志
2004年 第7期

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