期刊文献+

自由基对转录因子NF-κB活性的调节 被引量:13

The regulation of NF-κB by free radical
下载PDF
导出
摘要 核因子 κB(nuclearfactor kappaB ,NF κB)是普遍存在于真核细胞内的一个包含五种亚单位的转录因子家族 ,调节细胞内如免疫炎症、细胞凋亡和细胞增生相关基因等多种基因的表达。作者结合近年来对自由基和NF κB关系的研究进展作一综述 ,并讨论分析了自由基对NF Nuclear factor κB (nuclear factor kappa B, NF κB), a ubiquitous multisubunit eukaryotic factor comprised of five subunit regulates many genes expression including immune and inflammatory genes, apoptosis, and cell proliferation, et al . In this article, Relation of NF κB and free radical and free radical regulate the activity of NF κB were reviewed.
作者 徐康 林正
出处 《医学研究生学报》 CAS 2004年第7期654-656,共3页 Journal of Medical Postgraduates
关键词 自由基 NF-ΚB 氧化还原 Free radical NF κB Redox
  • 相关文献

参考文献16

  • 1[1]Sen R, Baltimore D. Inducibility of the immunuglobin enhancerbinding NF-κB by posttranslational mechanism[J]. Cell, 1986,47(6): 921-928.
  • 2[2]Haddad JJ, Lauterbach R, Saade NE et al. Alpha-melanocyterelated tripeptide, Lys-d-Pro-Val, ameliorates endotoxin-induced nuclear factor kappaB translocation and activation: evidence for involvement of an interleukin-lbeta193-195 receptor antagonism in the alveolar epithelium [ J ]. Biochem J, 2001,355 ( pti ): 29-38.
  • 3[3]Giatromanolaki A, Koukourakis MI, Sivridis E et al. Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable nonsmall cell lung cancer to angiogenic/molecular profile of tumours and survival[J]. Br J Cancer, 2001,85(6): 881-890.
  • 4[4]Kaul N, Choi J, Forman HJ. Transmembrane redox signaling activates NF-kappaB in macrophages [ J ]. Free Radic Biol Med,1998, 24( 1 ) :202-207.
  • 5[5]Fujita T, Nolan GP, Liou HC et al. The candidate protooncogene bcl-3 encodes a transcriptional coactivator that activates through NF-κB p50 homodimers[ J]. Genes, 1993, 7 (7B): 1354-1363.
  • 6[6]Sen R, Baltimore D. Multiple nuclear factors interact with the irmmunoglobulin enhancer sequences [ J ]. Cell, 1986,46 ( 5 ): 705 -716.
  • 7[7]Baeuerle PA, Baltimore D. NF-KB: 10 years after[J]. Cell,1996,87 ( 1 ): 13 -20.
  • 8[8]Chiao PJ, Miyamoto S, Verma IM. Autoregulation of I-κB activity[J]. Proc Natl Axad Sci USA, 1994, 91(1): 28-32.
  • 9[9]Lee FS, Hagler J, Chen ZJ et al. Activation of the I-κB kinase complex by MEKK1, a kinase of the JNK pathway [ J ]. Cell,1997, 88(2): 213-222.
  • 10[10]Zamanian DM, Mogensen TH, Didonato JA et al. NF-κB activation by double-stranded-RNA-activated protein kinase(PKR) is mediated through NF-κB-inducing kinase and ikkappaB kinase[ J ]. Mol Cell Biol, 2000,20 (4): 1278-1290.

同被引文献162

引证文献13

二级引证文献85

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部