电化学发光法CA19-9与CEA联合检测在胰腺癌诊断中的意义

Value of Combined Detection of CA19-9 and CEA with Electrochemiluminescence in Diagnosis of Pancreatic Cancer

目的 探索血清中肿瘤标志物CA19 9和癌胚抗原 (CEA)在胰腺癌诊断中的临床价值。方法 采用Elecsys10 10全自动电化学发光免疫分析仪测定 3 2例胰腺癌、3 2例良性胰腺病患者血清中的CA19 9、CEA的水平。结果 胰腺癌组CA19 9、CEA的测定值分别为 10 6.3± 79.1ng/ml和 3 1.8± 0 .7ng/ml ,均显著高于良性胰腺病组。 结论 CA19 9对胰腺癌的诊断价值高于CEA ,CA19 9与CEA联合检测对胰腺癌的诊断具有一定的临床意义。

Objective To investigate the clinical value of the tumor marker CA19-9 and carcinoembryonic antigen(CEA) in human serum in diagnosis of pancreatic cancer.Method The concentrations of CA19-9 and CEA in serum in thirty-two patients with pancreatic cancer and thirty-two patients with benign pancreatic disease were detected with Elecsys 1010 auto electrochemiluminescene immune analyzer.Results The levels of CA19-9 and CEA in the former group were 106.3±79.1ng/ml and 31.8±0.7ng/ml,which were significantly higher than those in the latter group.Conculsions The value of CA19-9 in diagnosis of pancreatic cancer is higher than that of CEA.But the combined detection of CA19-9 and CEA is clinically significant to diagnosis of pancreatic cancer.