α1受体阻滞剂治疗良性前列腺增生研究进展

Progress in the Studies of α_1-receptor Blocker for Benign Prostatic Hyperplasia

良性前列腺增生是常见的老年病 ,下尿路症状是其主要临床表现。近年来 ,下尿路症状困扰着广大老年男性患者。目前认为下尿路症状的发生与分布于前列腺的α1受体有关 ,α1受体阻滞剂是目前公认的治疗前列腺增生及其引起的下尿路症状的首选药物。本文对α1受体的组织分布、α1受体阻滞剂的临床应用进行了综述。

Benign prostatic hyperplasia (BPH) is a common senile disease,and its main clinical manifestation is lower urinary tract symptom (LUTS),which has long been afflicting old male patients. Previous study showed that α 1 -receptor in the prostate was involved in the development of LUTS. At present,α 1 -receptor blocker is generally accepted as a choice drug for treating BPH and relieving LUTS. The article reviews the tissue distribution of α 1 -receptor and clinical application of α 1 -receptor blocker.