绿芝宝对青藏铁路工人高原危害的防护作用

Protective Effects of Lüzhibao on Plateau Hazards of Workers Building Qing-zang Railway

目的 观察绿芝宝对青藏铁路工人高原危害的防护作用。方法 采用多阶段抽样方法抽取年龄2 0～ 4 8岁的筑路工人 1 80人 ,随机分为高原对照组、绿芝宝组、洋参组 ,同时设立平原对照组。分别于平原、进驻高原第 3～ 5天、饮用绿芝宝 90天后对各组人员进行流行病学调查、健康检查和实验室检查 ,并进行各组之间的比较。结果 绿芝宝组于饮用绿芝宝 90天后 ,与高原对照组进驻高原第 3～ 5天及第 90天相比 ,高原反应的症状明显减轻 ,血压均值及高血压检出率、红细胞总数、氧化损伤指标过氧化氢酶(CAT)、谷胱甘肽过氧化物酶 (GSH Px)、活力丙二醛 (MDA)含量均下降 ,超氧化物歧化酶 (SOD)活力增加 ,服用前后自身比较结果与前者一致。结论 绿芝宝对青藏铁路工人具有保健作用 ,可降低血压 ,减轻血液粘滞性 ,减轻高原反应的症状 ,改变各种抗氧化酶的活力 ,抑制脂质过氧化 。

Objective To study the protective effects of Lüzhibao on plateau hazards of workers building Qing zang railway.Methods 180 workers with the age of 20～48 were sampled by multistage sampling.They were divided randomly into three groups,i e.Lüzhibao group,American ginseng group and plateau control group.60 workers working in plain area is taken as the plain control.The plateau reactions,including blood pressure,blood routine and free radical indices were investigated and examined at first 5 days after arriving to plateau and 90 days after taking Lüzhibao.Differences between groups were compared.Results Compared with control group,various symptoms or indexes of plateau reaction in Lüzhibao group reduced,i e.mean value of blood pressure,the occurrence of hypertension,count of red blood cell,the activity of CAT and GSH Px in serum,and concentration of MDA in serum.The activity of SOD in serum increased.Conclusions It indicated that Lüzhibao could release plateau reaction,lower the blood pressure and blood viscosity,change the activity of serum anti oxidative enzymes,and inhibit the formation of lipid peroxide.The short term effect of Lüzhibao appeared significant.