1COLONNO RJ,GENOVESI EV,MEDINA I,et al.Long-term entecavir trertmont result in sustained antiviral efficacy and prolonged life span in the woodchuck model of chronic hepatitis infection[J].J Infect Dis,2001,184:1236-1245.
2WHO/OMS. Hepatitis B Facet Sheet[R].Infections Diseases,2000.
3MARION PL, SALAZAR FH,WINTERS MA,et al. Potent efficacy of entecavir(Bms-200475) in a duck model of hepatitis B virus replication[J].Antimicrob Agents Chemother,2002,46:82-88.
4JULANDER JG,COLONNO RJ,SIDWELL RW,et al.Charaterization of antiviral of entecavir in transgenic mice expressing hepatitis B virus[J].Antiviral Res,2003,59(3):155-161.
5DE MON RA,WOLTERS LMM,NEVENS F,et al.Safety and efficacy of oral entecavir given for 28 days in patients with chronic hepatitis b virus infection[J].Hepatology,2001,34(3):578-582.
6CHANG T.T HADZIYANNIS.S,CIANCIARA,et al.Sustaired viral.load.amnd ALT.reduction following 48 weeks of entecavir treatment subjects.with.chronic hepatitis B.who.have failed lamration[J].Hepatology,2002,36:A300.
7LAI CL,ROSMAWATI M,LAO J,et al.Entecavir is superior to lamirudine in reduing hepatitis B virus DNA in patients with chronic hepatitis B infection[J].Gastroenteroloyy,2002,123(6:)1831-1838.
8LEE WN.Hepatitis B virus Infection[J].N Engl J med,1997,337:1733-1745.
9HADZIYANNIS SJ,PAPATHEODORIDIS GV.Efficaly of long-term Lamirudine nonotherapy in patients with hepatitis B e antigen-negative chronic hepatitis.[J]B Hepatology,2000,32:847-851.
10SANTANTONIO T,MAZZOLAM.Long-term follow-up of pationts with anti-hBel/HBv-DNA-positive chronic hepatitis B treated for 12 months with lamirudine[J].J hepatol,2002,3(2):300-306.
