血清PAB、AAG、C_3、C_4的检测在肝病诊断中的意义

The significance of measurement of serum PAB,AAG, C_3 and C_4 in diagnosis of liver diseases

目的探讨血清前白蛋白(PAB)α1-酸性糖蛋白(AAG)及补体C3、C4在肝脏疾病诊断中的临床意义。方法采用免疫散射比浊法测定各种类型肝病患者血清中的PAB、AAG、补体C3、C4的含量,并与正常对照组比较。结果各型肝病中的PAB都有不同程度的下降,急性肝炎和肝癌中的AAG明显增高,慢性肝炎、肝硬化及重肝中的AAG明显下降。急性肝炎及肝癌的C3、C4明显升高。其他各型肝病均有不同程度的下降。结论PAB、AAG、C3、C4联合检测对肝脏疾病有非常重要的诊断价值。

Objective In order to study the clinical significance of serum prealbumin (PAB) a1-acid glycoprotein(AAG),complements C3 and C4 in diagnosis of liver diseases. Method Nephelometry was employed to measure the levels of serum PAB,AAG,C3 and C4 in patients with various liver diseases and that was compared with control group. Results The level of serum PAB declined in different degree in patients with various liver diseases. The level of serum AAG in patients with acute hepatitis and hepatocellular carcinoma increased obviously. In patients with chronic hepatitis, liver cirrhosis and severe viral hepatitis ,AAG declined dramatically. The levels of serum C3 and C4 went up obviously in patients with acute hepatitis and hepatocellular carcinoma ,and declined in patients with other liver diseases. Conclusion United-tests of serum PAB, AAG, C3 and C4 have important value in diagnosis of liver diseases.