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丝裂原活化蛋白激酶信号转导通路与骨质疏松 被引量：2

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摘要 丝裂原活化蛋白激酶(MAPK)是信号从细胞表面传导到细胞核内部的重要传递者,包括细胞外信号调节激酶(ERK)、p38、c-Jun氨基末端激酶(JNK)和ERK5。某些与骨质疏松相关的因子如核因子-κB受体活化因子配体(RANKL)、白介素(IL)-1、IL-6、转化生长因子-β、骨形态形成蛋白等通过与MAPK信号转导通路相互作用,参与了成骨细胞和破骨细胞的分化、增殖和凋亡的信号转导,在骨质疏松症的发生中发挥了重要作用。
作者 彭文芳 张秀珍
机构地区 同济大学附属同济医院内分泌科
出处 《国外医学（内分泌学分册）》 2004年第4期233-236,共4页 Foreign Medical Sciences(Section of Endocrinology)
基金 国家自然科学基金资助项目(30070357)
关键词 丝裂原活化蛋白激酶 信号转导通路 骨质疏松 MAPK 细胞核
分类号 R58 [医药卫生—内分泌]
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参考文献19

  • 1Sowa H, Kaji H, Yameguchi T, et al. Activations of ERK1/2 and JNK by transforming growth factor beta negatively regulate Smad3-induced alkaline phosphatase activity and mineralization in mouse osteoblastic cells. J Biol Chem, 2002,277: 36024-36031.
  • 2Rawadi G,Ferrer C,Spinella-Jaegle S,et al. 1-(5-oxobexyl)-3,7-Dimethylxanthine, a phosphodiesterase inhibitor, activates MAPK cascades and promotes osteoblast differentiation by a mechanism independent of PKA activation (pentoxifylline promotes osteoblast
  • 3Swarthout JT, Doggett TA, Lemker JL, et al. Stimulation of extracellular signal-regulated kinases and proliferation in rat osteoblastic cells by parathyroid hormone is protein kinase C-dependent. J Biol Chem, 2001,276: 7586-7592.
  • 4Engelbrecht Y, de Wet H, Horsch K, et al. Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast ce
  • 5Miwa M, Kozawa O, Tokuda H, et al. Mitogen-activated protein (MAP)kinaaes are involved in interleukin-1 (IL-1)-induced IL-6 synthesis in osteoblasts: modulation not of p38 MAP kinase, but of p42/p44 MAP kinase by IL-l-activated protein kinase C. Endocrino
  • 6Lai CF, Chaudhary L,Fausto A,et al. Erk is essential for growth,differentiation, integrin expression, and cell function in human osteoblastic cells. J Bio1 Chem,2001,276:14443-14450.
  • 7Kondo A, Koshihara Y, Togari A. Signal transduction system for interleukin-6 synthesis stimulated by lipopolysaccharide in human osteoblasts. J Interferon Cytokine Res,2001,1:943-950.
  • 8Chae HJ, Chae SW, Chin HY, et al. The p38 mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumor necrosis factor in osteoblasts. Bone,2001,28:45-53.
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国外医学（内分泌学分册）
2004年 第4期

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