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结缔组织生长因子与软骨细胞及成骨细胞的增殖分化 被引量：1

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摘要 肥大带软骨细胞和功能活跃的成骨细胞均可高水平表达结缔组织生长因子(CTGF),CTGF可促进软骨细胞和成骨细胞的增殖,促进软骨细胞(如X型胶原)和成骨细胞相关表型(如碱性磷酸酶、Ⅰ型胶原)的发生,在骨和软骨的发育以及骨量维持方面发挥重要作用。另外,CTGF还参与了骨折愈合及病变软骨的修复过程。转化生长因子-β、前列腺素E2等可能参与了CTGF基因表达的调控。
作者 翟木绪 廖二元 彭依群
机构地区 中南大学湘雅二医院代谢内分泌研究所
出处 《国外医学（内分泌学分册）》 2004年第4期250-252,共3页 Foreign Medical Sciences(Section of Endocrinology)
关键词 结缔组织生长因子 软骨细胞 成骨细胞 细胞增殖 细胞分化 CTGF 基因调空
分类号 R68 [医药卫生—骨科学]
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参考文献14

  • 1Nakanishi T, Nishida T, Shimo T, et al. Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture.Endocrinology,2000,141:264-273.
  • 2Nishida T,Kubota S,Nakanishi T,et al.CTGF/Hcs24,a hypertrophic chondrocyte specific gene product,stimulates proliferation,and differentiation,but not hypertrophy of cultured articular chondrocytes.J Cell Physiol,2002,192:55-63.
  • 3Nakanishi T,Yamaai T,Asano M,et al.Overexpression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 decreases bone density in adult mice and induces dwarfism.Biochem Biophys Res Commun,2001,281:678-681.
  • 4Nishida T,Kubotal S,Kojima S,et al.Regulation of defects in the articular cartilagein rat knee joints by connectivetissue growthfactor/hypertrophic chondrocyte-specific gene production 24(CTGF/HCS24).JSBMR WORKSHOP 1:Differentiation and Regeneration of Bo
  • 5Kumar S, Hand AT,Connor JR,et al. Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encodinga novel regulator of osteoblast functions. J Biol Chem, 1999,274:17123-17131.
  • 6Safadi FF, Xu J, Smock SL, et al. Expression of connective tissue growth factor in bone:its role in osteoblast proliferation and differentiation in vitro and bone formation in vivo. J Cell Physiol, 2003,196: 51-62.
  • 7Goppelt-Struebe M, Hahn A, Iwanciw D, et al. Regulation of connective tissue growth factor (ccn2, ctgf) gene expression in human mesangial cells: modulation by HMG CoA reductase inhibitors (statins). J Clin Pathol Mol Pathol, 2001,54:176-179.
  • 8Takigawa M,Nakanishi T,Kubota S,et al. Role of CTGF/HCS24/Ecogenin in skeletal growth control. J Cell Physiol, 2003,194:256-266.
  • 9Nishida T,Nakanishi T,Asano M,et al.Effects of CTGF/Hcs24,a hypertrophic chondrocyte-specific gene product,on the proliferation and differentiatinn of osteoblastic cells in vitro.J Cell Physiol,2000,184:197-206
  • 10Nakata E, Nakanishi T, Kawai A, et al. Expression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 (CTGF/Hcs24) during fracture healing. Bone,2002,31:441-447.

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国外医学（内分泌学分册）
2004年 第4期

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