自然组织谐波成像后心肌背向散射积分定量评价尿毒症患者心肌病变

Myocardial damage in patients with uremia by myocardial integrated backscatter measured on native tissue harmonic imaging

目的 探讨尿毒症患者基波及自然组织谐波成像后左室心肌背向散射积分的变化及临床意义。方法 测定 2 2例尿毒症患者和 2 6例正常人基波及谐波成像后胸骨旁左室长轴切面室间隔和左室后壁的心肌背向散射积分参数。结果 ①尿毒症组在基波及谐波成像时左室心肌的IBS %均显著高于对照组 ,CVIB显著低于对照组 (P <0 .0 5 )。②谐波成像时尿毒症组左室心肌的IBS %较基波显著增高 ,CVIB显著增大 (P <0 .0 5 )。结论 背向散射技术可检测尿毒症患者心肌组织的微细结构变化 。

Objective To study the value of left ventricular myocardial integrated backscatter (IBS) measured on the condition of fundamental imaging and native tissue harmonic imaging in assessing the changes of myocardium in patients with uremia. Methods Myocardial integrated backscatter parameters, including IBS% and CVIB of the interventricular septum (IVS) and left ventricular posterior wall (LVPW), were assessed on the condition of fundamental imaging and native tissue harmonic imaging with HP Sonos-5500 imaging system in 22 patients with uremia and 26 normal subjects. Results ①Whatever the condition of fundamental or harmonic imaging, the IBS% of IVS and LVPW in the patients with uremia were higher than that of normal subjects, but the CVIB was lower than that of controls ( P <0.05). ②The IBS% and the CVIB of IVS and LVPW in the patients with uremia measured on the condition of harmonic imaging were significantly higher than that measured on fundamental imaging ( P <0.05). Conclusion The technique of integrated backscatter might be valuable in assessing the microstructural changes of myocardial tissue in patients with uremia, and the sensitivity is higher on the condition of second harmonic imaging than that of fundamental state.