脱细胞真皮移植在整形外科的应用

Clinical Application of Acellular Dermic Graft in Plastic Surgery

目的 探讨应用脱细胞异体真皮与自体表皮复合移植 ,修复四肢关节部位创面的临床效果。方法 关节挛缩瘢痕、巨大色素痣和皮肤广泛毛细血管瘤切除后 ,以脱细胞异体真皮与自体表皮构成复合皮 ,I期移植修复创面 ,创面最小 7cm× 11cm ,最大 12cm× 19cm ,其中肘关节部位 8例 ,踝关节部位 7例 ,膝关节部位 6例 ,腕关节部位 4例。观察移植复合皮的成活率及愈合皮片色泽、质地和关节功能改善情况。结果 临床应用 2 5例 ,术后移植复合皮成活率 92 9% ,随访 3个月～ 2年 ,移植皮片颜色与周围正常皮肤颜色接近 ,皮片柔软 ,瘢痕增生不明显 ,关节功能较术前显著改善。结论 组织工程化脱细胞异体真皮和自体表皮复合移植修复关节部位的创面不失为一种较理想的方法 。

Objective To investigate the clinical effect of acellular allogenic dermis combined with split-thickness autogenous skin graft for coverage of wound in extremity joint. Methods After contraction scar, giant pigmented nevus and capillary hemangioma being removed, acellular allogenic dermis with split-thickness autogenous skin graft was used to repair 25 cases of wounds of elbow, ankle, knee and wrist joints. The area of wounds was from 7cm×11cm to 12cm×19cm. Out of 25 wounds, there were 4 in wrist, 8 in elbow, 7 in ankle and 6 in knee joints. The survival rate of graft skin and improvement degree of joint function were observed. Results All grafts survived and had the smooth surface without obvious pigmentation and wound contraction. The function of joint was significantly improved after operation. Conclusion Tissue-engineered dermis with autogenous epithelium is an ideal graft for coverage of various wounds in extremity joint.