影响体外受精-胚胎移植相关因素的探讨

The Study of Association Factors Affecting IVF/ICSI-ET

目的 探讨影响体外受精 -胚胎移植 (IVF -ET)的相关因素。方法 回顾性分析多种因素不孕行IVF/ICSI -ET的3 48个周期的临床资料。结果 随年龄增长卵巢储备与卵巢反应均下降 ;bFSH预测卵巢储备能力有限 ,随bFSH增长E2 峰值、大卵泡数、获卵数均降低 ;大卵泡数和获卵数随E2 峰值升高均显著增加 ;窦卵泡数、卵巢体积与卵巢反应性正相关 ;但尚无一项指标能单独预测IVF结局。结论 年龄与卵巢储备、卵巢反应性的关系更为紧密 ;bFSH只是反映卵巢储备功能的指标之一 ,其预测卵巢反应性及IVF结局的能力有限 ;E2 峰值无法预测IVF结局 ;总窦卵泡数与卵巢体积是反映卵巢反应性最直接的指标。应全面综合评估病人条件 ,更好的提高IVF/ICSI

Objective To investigate the association factors affecting the course of IVF/ICSI-ET. Methods The clinical data of 348 cycles of IVF/ICSI-ET in patients with different causes of infertility were analyzed retrospectively. Results Ovarian reserve and response to stimulation declined with aging. The ability of bFSH predicting ovarian response was low. E 2 peak concentration, number of big follicle and retrieved oocytes decreased significantly when bFSH concentration evelated. The number of big follicle and retrieved oocytes obviously increased with the E 2 peak concentration increasing. The number of antral follicle and volume of ovary were positive relation with ovarian response. None of the factors above could predict the outcome of IVF indenpedently. Conclusion Age was strongly associated with ovarian reserve and response. The bFSH level was one of the indices reflecting ovarian reserve, and had the limited capability for predicting ovarian response and IVF outcome.E 2 peak concentration could not predict the IVF consequence. The number of total antral follicle and volume of ovary were the most direct index reflecting ovarian response. The conditions of patients should comprehensively be evaluated to raise the pregnant rate of IVF.