养心定悸冲剂治疗快速性心律失常的临床研究

Clinical research of the curative effect of Yangxin Dingji medicinal granules(养心定悸冲剂) on rapid arrhythmia

目的 :观察养心定悸冲剂治疗快速性心律失常的临床疗效。方法 :采用对照研究方法 ,将 16 3例快速性心律失常患者随机分为治疗组 10 5例、对照组 5 8例 ,分别口服养心定悸冲剂和稳心颗粒 ,两组疗程均为4周。分析两组心肾不交、肝肾阴虚、气阴两虚、气滞血瘀和阳虚湿阻不同证型与临床疗效的关系。结果 :治疗组显效率 (4 5 .72 % )和总有效率 (86 .6 7% )均优于对照组 (显效率 32 .76 % ,总有效率 74 .14 % ,P均 <0 .0 5 ) ,心肾不交证及肝肾阴虚证的总有效率 (95 .83%和 92 .31% )亦均明显优于对照组 (分别为 71.4 3%和 6 9.2 3% ,P均 <0 .0 5 ) ;治疗组室上性心动过速的疗效差 ,其余各证型之间无差别。而对照组治疗各证型心律失常的疗效无明显差异。结论 :养心定悸冲剂对快速性心律失常有较好的临床治疗效果 ,尤其对期前收缩、阵发性房性心动过速、心房颤动、窦性心动过速效果明显 ,对中医辨证为心肾不交证、肝肾阴虚证、气阴两虚证的效果较好。

Objective: To observe the clinical curative effect of Yangxin Dingji medicinal granules(养心定悸冲剂) on rapid arrhythmia. Methods: By the control methods, 163 patients with rapid arrhythmia were randomly divided into two groups, 105 cases in the treatment group and 58 cases in the control group. The two groups were taken Yangxin Dingji medicinal granules, and Wenxin granule(稳心颗粒) separately, and treatment course was four weeks for each group. The relationship of the clinical effects and traditional Chinese syndromes and types 〔including disharmony between the heart and kidney(心肾不交证), deficiency of (liverYin) and kidneyYin(肝肾阴虚证), deficiency of both Qi and Yin(气阴两虚证), Qi stagness and blood stasis(气滞血瘀证), deficiency of Yang and retention of dampness(阳虚湿阻证)〕 was analysed. Results: The (apparent) rate and total effective rate in the treatment group(45.72% and 86.67%) were better than those of the control group (32.76% and 74.14%, both P<0.05). The total curative effect in the treatment group of suffering disharmony between the heart and kidney as well as deficiency of liverYin and kidneyYin(95.83% and 92.31%) were better than those of the control group(71.43% and 69.23%, both P<0.05). In the treatment group, the curative effect of supraventricular tachycardia was bad, there was no difference (among) the other types. In the control group, there was no difference of (curative) effect among all types of (arrhythmia). Conclusion: Yangxin Dingji medicinal granules has better clinical curative effect on rapid (arrhythmia), especially on premature beat, paroxysmal atrial tachycardia, atrial fibrillation and sinus (tachycardia), which are disharmony between the heart and kidney, deficiency of liverYin and kidneyYin as well as deficiency of both Qi and Yin according to the syndrome differ classification of traditional Chinese medicine.