参麦注射液及复方丹参注射液合用对急性心肌梗死患者介入治疗后再灌注损伤的影响

Effect of Combined Therapy of Shenmai and Compound Danshen Injection on Myocardial Reperfusion Injury after Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction

目的探讨参麦注射液及复方丹参注射液合用对急性心肌梗死患者冠状动脉介入治疗 (PCI)后心肌再灌注损伤的影响。方法选择接受PCI的 38例急性心肌梗死患者 ,随机分为治疗组 (19例 )与对照组 (19例 ) ,治疗组术前及术后给予参麦注射液及复方丹参注射液治疗。分别在术前及术后不同时间点测定血清丙二醛 (MDA)、超氧化物歧化酶 (SOD)、白细胞介素 6 (IL 6 )、肿瘤坏死因子 (TNF α)水平 ,用超声心动图测定左心室综合射血等容期 (Tei)指数。结果与术前比较 ,治疗组术后 2h、2 4h静脉血MDA升高、SOD降低 (P <0 0 5 ) ;IL 6及TNF α术后 2 4h、4 8h、1周时明显降低 (P <0 0 5 ,P <0 0 1) ;Tei指数术后 2 4h就有所改善 (P <0 0 5 ) ,1周明显改善 (P <0 0 1)。对照组术后 2h、2 4h静脉血MDA明显升高、SOD明显降低 (P<0 0 1) ;IL 6、TNF α术后 1周才出现降低 (P <0 0 5 ) ;Tei指数术后 1周有所改善 (P <0 0 5 )。两组比较 ,血清MDA、SOD术后 2h、2 4h差异有显著性 (P <0 0 1) ;IL 6、TNF α术后 2 4h、4 8h、1周时差异有显著性 (P<0 0 5 ) ,Tei指数术后 2 4h、1周差异亦有显著性 (P <0 0 5 )。

ObjectiveTo explore the effect of combined therapy of Shenmai and Compound Danshen injection (SM DS) on myocardial reperfusion injury after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). MethodsThirty eight AMI patients who received PCI were randomly divided into two groups, the 19 patients in the treated group were treated with SM DS before and after PCI. Serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), interleukin 6 (IL 6) and tumor necrosis factor α (TNF α) in patients' venous blood were measured at different time points, and the integrated left ventricular ejection isometric index (Tei) was determined by echocardiogram. ResultsAs compared with before operation in the treated group, MDA was higher and SOD was lower at 2 hrs, 24 hrs after operation (P<0 05); IL 6 and TNF α were significantly lower at 24 hrs, 48 hrs and 1 week (P<0 05, P<0 01) and the Tei began to be improved at 24 hrs (P<0 05) and significantly improved at 1 week after operation (P<0 01). While in the control group, MDA was higher and SOD was obviously lower at 2 hrs and 24 hrs (P<0 01); lowering of IL 6 and TNF α appeared at 1 week (P<0 05) and improving of Tei index revealed 1 week after operation respectively (P<0 05). Comparison between the two groups showed significant difference in levels of MDA and SOD at 2 hrs and 24 hrs (P<0 01); significant difference in levels of IL 6, TNF α at 24 hrs, 48 hrs and 1 week; and in Tei index at 24 hrs and 1 week after operation (P<0 05). ConclusionSM DS could reduce the myocardial reperfusion injury in patients with AMI after PCI.