非小细胞肺癌微血管密度与血管内皮生长因子表达的研究

Study of Microvessel Density and Vascular Endothelial Growth Factor in Non-small Cell Lung Cancer

目的 研究微血管密度 (MVD)与血管内皮生长因子 (VEGF)表达与非小细胞肺癌 (NSCLC)生物学行为及其预后的关系。方法 应用免疫组化方法检测 5 6例NSCLC和 16例正常肺组织中MVD、VEGF的表达。结果 (1)NSCLC与正常肺组织MVD、VEGF的表达具有显著性差异 (P <0 .0 1) ,肺癌MVD随VEGF表达的增强而增多 ,两者呈正相关。(2 )MVD和VEGF的表达在肺腺癌中显著高于肺鳞癌 (P <0 .0 5 ) ,两者随淋巴结转移、TNM分期的进展而升高 (P <0 .0 5 )。(3)生存期 <2年者MVD和VEGF的表达显著高于生存期 >2年者 (P <0 .0 5 )。结论 MVD和VEGF的表达与NSCLC发生、发展、转移关系密切 ,可作为NSCLC生物学行为及预后判断的指标。

Objective To investigate the correlation between the microvessel density(MVD) and expression level of vascular endothelial growth factor(VEGF) and biological behavior of non-small cell lung cancer(NSCLC) and its prognosis. Methods MVD and VEGF expression in 56 cases of NSCLC and 16 cases of nomal lung tissues was tested with immunohistochemistry methods. Results (1)significant differences in MVD and VEGF expression were found between NSCLC and nomal lung tissues (P<0.05),lung cancer MVD increased with the increase of the VEGF expression,they had positive relation.(2)MVD and VEGF expression in lung adenocarcinoma was higher than that in squamosumcarcinoma (P<0.05),they increased with the lymphnode metastasis and advancing of TNM Stage (P<0.05).(3)Between the survival time in the group less than 2 years and the group more than 2 years, both MVD and VEGF expression had significant difference(P<0.05).Conclusion MVD and VEGF are closely related to the occurrence,development and metastasis of NSCLC, they can be used as a major judgement parameter for biological behavior and prognosis of NSCLC.