卡维地洛治疗慢性充血性心力衰竭的临床研究

Clinical study of carvedilol treatment in chronic heart failure

目的研究卡维地洛治疗慢性充血性心力衰竭 (CHF)的临床疗效及安全性。方法 96例CHF患者随机分为 2组 ,卡维地洛在对照组治疗的基础上 ,加服卡维地洛 ,对照组采用常规治疗方法 (ACEI、利尿剂、地戈辛 )。治疗 3个月后 ,评价心功能 ,检查超声心力图 2次 (治疗前后 )。检查治疗前后肝、肾功能。结果卡维地洛治疗组显示心功能明显改善 (p <0 .0 5 ) ,左心室射血分数明显增加 (p <0 .0 5 ) ,未发现肝、肾功能恶化。结论卡维地洛在常规治疗CHF的基础上 ,对CHF患者安全有效 ,可作为CHF的常规治疗。

Objective To study clinical efficacy and safety of carvedilol in chronic heart failure. Methods 96 patients with chronic heart failure were divided into two groups. Carvedilol was added on basic therapy in 48 patients as threatment group. Other 48 patients were given basic therapy including ACEI, diuretic and digoxin. All patients were examined with echocardiography and liver and renal function for two times during a six-month periodi.Results Treatment group could improve heart function remarkably, increase LVEF. There was no significant difference of adverse reaction between the two groups. No significant change of liver, renal function.Conclusion Carvedilol was added on basic therapy in patient with CHF, Which is a quite safe and very effective.