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CD_(20)单克隆抗体联合自体干细胞移植治疗非霍奇金淋巴瘤 被引量：1

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摘要 大剂量放、化疗结合自体干细胞移植(ASCT)虽然可明显提高非霍奇金淋巴瘤(NHL)患者的缓解率,延长其缓解期,但最终仍有40%～70%的患者复发.CD20单克隆抗体(CD20mAb)通过独特的机理可以有效地清除移植物中污染的肿瘤细胞以及移植后残存的少量肿瘤细胞而明显提高了ASCT的疗效.本文就CD20mAb在ASCT治疗NHL中的移植前化疗、体内外净化、预处理及移植后巩固治疗等方面的应用进行综述.
作者 李桥川 孙洪波 李云涛 邱录贵
机构地区 中国医学科学院中国协和医科大学血液学研究所血液病医院
出处 《国外医学（输血及血液学分册）》 2004年第4期342-345,共4页 Foreign Medical Sciences(Section of Blood Transfusion and Heanatology)
关键词 CD20单克隆抗体 联合 自体干细胞移植 治疗 非霍奇金淋巴瘤
分类号 R733.1 [医药卫生—肿瘤]
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参考文献30

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同被引文献5

  • 1van Heeckeren W J,Vollweiler J,Fu P,et al.Randomised comparison of two B-cell purging protocols for patients with B-cell nonHodgkin lymphoma:in vivo purging with rituximab versus ex vivo purging with CliniMACS CD34 cell enrichment device[J].Br J Haematol,2006,132(1):42-55.
  • 2Jacquy C,Soree A,Lambert F,et al.A quantitative study of peripheral blood stem cell contamination in diffuse large-cell nonHodgkin's lymphoma:one-half of patients significantly mobilize malignant cells[J].Br J Haematol,2000,110(3):631-637.
  • 3Lazzarino M,Arcaini L,Bernasconi P,et al.A sequence of immunochemotherapy with Rituximab,mobilization of in vivo purged stem cells,high-dose chemotherapy and autotransplant is an effective and non-toxic treatment for advanced follicular and mautle cell lymphoma[J].Br J Haematol,2002,116(1):229-235.
  • 4Voso M T,Pantel G,Weis M,et al.In vivo depletion of B cells using a combination of high-dose cytosine arabinoside/mitoxantrone and rituximab for autografting in patients with non-Hodgkin lymphoma[J].Br J Haematol,2000,109(4):729-735.
  • 5Magni M,Di Nicola M,Devizzi L,et al.Successful in vivo purging of CD34-containing peripheral blood harvests in mantle cell and indolent lymphoma:evidence for a role of both chemotherapy and rituximab infusion[J].Blood,2000,96(3):864-869.

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国外医学（输血及血液学分册）
2004年 第4期

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