中间锦鸡儿中的倍半萜类化合物

Sesquiterpenes from Caragana Intermedia

从中间锦鸡儿 (Caraganaintermedia)地上部分分离得到二个新的倍半萜类化合物 ,即桉烷 4( 15 ) 烯 1β ,8α 二醇 ( 1)和反式 -八氢茚 7β 异丙基 4 亚甲基 9β 甲基 1 β 醇 ( 2 ) ,其中化合物 2为桉烷类化合物中一种新的碳架 ;四个已知化合物 ,即异香木兰烷 3 β,9β 二醇 ( 3 ) ,( +) 3α ,9β 香木兰烷二醇 ( 4 ) ,( +) spathulenol ( 5 ) 和 ( +) lariciresinol( 6) .制备了以及化合物 5的衍生物 ( +) 1 0α 溴 spathulenol( 7) .其中化合物 1 ,2 ,3 ,4,5 ,7分别在 3 8,1 0 ,2 5 ,1 8,9,3 5 μg/mL浓度时对稻瘟霉P 2b有完全抑制作用 .以上分得的化合物及衍生物通过 1D ,2D核磁共振、高分辨质谱、红外等光谱方法确定结构 ,其中化合物 4通过X单晶衍射对其结构进行了进一步确证 .

Two novel sesquiterpenoids, eudesm-4(15)-ene-1β,8α-diol (1) and trans-octahydroindane-7β-isopropyl-4-methylene-9β-methyl-1β-ol (2), four known compounds, alloaromadendrane-3α,9α-diol (3), (+)-3α,9β-aromaden-dranediol (4), (+)-spathulenol (5) and (+)-lariciresinol (6), were isolated from an aerial part of Caragana intermedia. (+)-10α-Bromospathulenol (7) was prepared from compound 5. Compounds 1, 2, 3, 4, 5 and 7 showed anti-pyriculariaoryzae P-2b activity with MIC value of 38, 10, 25, 18, 9 and 35 μg/mL, respectively. The structures of these compounds were determined by spectral data including 1D, 2D NMR, IR and HRMS spectra. Compound 4 was confirmed by X-ray crystallographic analysis.