绝经前后原发性高血压患者脂蛋白(α)及血脂水平变化的分析

Clinical study the changes of serum lipoprotein(α) and lipid levels in pre-and post-menopausal hypertensive women

目的 研究绝经前后女性原发性高血压患者脂蛋白 (α)及血脂变化的特点 ,探讨其对女性冠心病发病情况的影响。方法 女性原发性高血压患者 118例 ,绝经前后 6 0例 ,绝经后 5 8例 ,测定脂蛋白 [LP(α) ]、总胆固醇 (TC)、甘油三酯 (TG)、低密度脂蛋白胆固醇 (LDL -C)和高密度脂蛋白胆固醇 (HDL -C)。对比绝经前后LP(α)及血脂水平的变化 ,并与健康体检女性 118例作对照。结果 高血压组LP(α)、TC、TG、LDL -C均显著高于对照组 ,而LDL -C则明显低于对照组 ,绝经后患者LP(α)、TC、TG、LDL -C明显高于绝经前患者 ,而HDL -C则前者低于后者。结论 女性绝经后原发性高血压患者LP(α)、TC、LDL -C均明显高于绝经前患者 ,提示血脂水平的变化是绝经后冠心病发病率明显上升的重要危险因素。

Objective To study the changes of serum lipoprotein(α) and lipid levels in pre-and post-menopaused hyperfensive women and to investigate.It influences on the prevalance condition of female coronary heart disease.Methods 118 female hypertensives were collected for the determination of serum LP(α),total cholesterol(TC),trigly cerides(TG),low density lipoprotein cholesterol(LDL-C) and high density lipoprotein cholesterol(HDL-C).The serumpl(α) and lipid levels were compared between pre-and post-menopansal subgrouys,as well between hypertensives and a control group of 118 healthy women.Results Hypertensives group had synificantly higher LP(α),TC,TG and LDL-C,lower HDL-C than the control group.In post-menopausal group LP(α).TC,TG,LDL-C were significantly higher,but HDL-C was lower than those in pre-menopausal group.Conclusions In post-menopausal hypertensives,the levels of LP(α),TC,LDL-C,TG are significantly higher than pre-menopausal hypertensives.It suggests that the change of serum lipid level is an important reason of the higher prevalence rate of cononary heart disease in the post-menopausal women. [