抗流感病毒抗生素研究开发进展(英文)

Research advances in the anti-influenza antibiotics

流感是严重危害人类健康的急性病毒性呼吸道传染病 ,由于流感病毒抗原变异 ,常规疫苗尚不能有效预防流感的暴发与流行。因此 ,抗流感病毒药物研究在流感治疗中具有重要意义。本文就近年来国外抗流感病毒药物研究进展 ,包括微生物来源的新型抗生素司他弗林 (stachyflin)和乙酰司他弗林 (acetylstachyflin) ,FR1982 4 8,FR1915 12 ,10 - norparvulenone的发现 ,以及经计算机分子模拟设计的氨基酸类 NA抑制剂、环戊烷类 NA抑制剂 RWJ- 2 70 2 0 1(BCX- 1812 )等的开发情况进行概述。

Human influenza viruses cause infectious diseases of the respiratory tract throughout the world. Although vaccines have been used to control influenza virus infection in human, their usage is considerably limited by frequent changes in the viral surface glycoproteins. This has led to focus on the development of anti-influenza drugs for treatment and prophylaxis. The research advance in the anti-influenza agents including the novel antibiotics from microorganisms, stachyflin and acetylstachyflin, FR198248, FR191512 & 10-norparvulenone; and novel amino acid neuraminidase inhibitor & cyclopentane neuraminidase inhibitor which are both discovered through structure-based drug design with computer on foreign recently has been described.