山莨菪碱辅助治疗急性分泌性中耳炎的临床研究

Adjuvant treatment of anisodamine to acute serous otitis media

目的 :评估山莨菪碱对急性分泌性中耳炎的辅助治疗作用。方法 :将 6 1例确诊为急性分泌性中耳炎患者随机分为两组 :对照组 30例 ,给予 1%新麻液 (新霉素加麻黄素 )滴鼻 ,口服开瑞坦 10mg/次 ,1次 /d ;西力欣 2 5 0mg/次 ,3次 /d。山莨菪碱组 31例 ,一般治疗同对照组 ,加服山莨菪碱 ,10mg/次 ,2次 /d。在治疗 5、10d时 ,比较两组治疗效果。结果 :治疗 5d时 ,山莨菪碱组患者听力改善率、耳鸣消失率、鼓室积液吸收率及咽鼓管功能曲线正常率明显高于对照组 (P <0 .0 5或P <0 .0 1) ;治疗 10d时 ,患者听力改善率、耳鸣消失率和鼓室积液吸收率 ,两组差异无统计学意义 (P >0 .0 5 ) ,但山莨菪碱组咽鼓管功能曲线正常率明显高于对照组 (P <0 .0 1)。结论

Objective:To evaluate the adjuvant treatment of anisodamine to acute serous otitis media.Method:Sixty-one acute otitis media patients were divided randomly into two groups.Group A with 30 patients were treated with 1% ephedrine nosedrop,antibiotic and antihistamine.Group B with 30 patients were treated with 1% ephedrine nose drops,antibiotic, antihistamine and anisodamine.They took anisodamine 10 mg twice a day.Then the treating efficiency of group A was compared with that of group B in 5 days and 10 days respectively.Result:The symptoms including hearing loss, tinnitus,hydrotympanum and eustachian tube function of group B recover more guickly than that of group A.Conclusion:Anisodamine adjuvant treatment of acute serous otitis media by improving the function of eustachian tube and microcirculation.