甲壳胺作为热固化型丙烯酸树脂义齿基托抑菌剂的应用

Experimental Studies on Bacterio-stasis of Heat-cured Polyacrylic Resin Denture Base when Added Chitosan

目的 初步探讨应用甲壳胺纤维作为热固化型丙烯酸树脂义齿基托材料抑菌剂的可行性。方法 分实验组 (含 2 %甲壳胺纤维 )和对照组两组 ,用维氏硬度比较硬度的差异 ;用微需氧培养和玻璃电极的方法 ,比较两组对口腔致龋链球菌生长和产酸的差别 ;用连续培养的方法比较两组试件表面对龈下混合菌黏附的差异。结果 实验组的维氏硬度显著提高 (P <0 .0 1) ,对变形链球菌的生长和产酸有显著的抑制作用 (P <0 .0 5 ) ,并能减少龈下混合菌的黏附 (P <0 .0 5 )。

Purpose: To evaluate the feasibility of chitosan for its bacteriostasis to heat-cured polyacrylic resin denture base material. Methods: This study was carried on between experimental group (with 2% chitosan) and control group(with no chitosan). Several studies were taken on to seek differences between the two groups: (1) to determine the change of Vickers hardness, (2) to learn the effect on the proliferation and H+ production of oral streptococci by microaerophilic culture and glass electrode, (3) to detect the different adhesiveness of bacteria to the surface of the experimental group with continuous culture method. Results: There were observed significant differences between two groups in the following aspects: (1) the Vickers hardness(P<0.01), (2) the inhibition of proliferation and H+ production of oral streptococci(P<0.05), (3) the inhibition to the adhesiveness of mixed subgingival bacteria to the surface of different material(P< 0.05). Conclusions: Chitosan can give the bacteriostasis of heat-cured resin denture base material.