德巴金缓释片治疗儿童癫痫中依从性的研究

The study of dependence on depakine chrono therapy for treating pediatric epilepsy

目的 :探讨德巴金缓释片抗癫痫治疗中脱落原因及对策。方法 :通过对我院开放性临床实验中德巴金缓释片(DK)抗癫痫治疗的87例患儿进行调查,并利用多元Logistic回归分析对34例最后放弃服用德巴金缓释片的患儿进行退出原因分析。结果 :(1)退出患儿占全部入组患儿的39.08 %(34/87);继续用药患儿为60.92 %(53/87)。(2)较常见的不良反应为肝功能损害、脱发、血小板减少、精神行为异常等。(3)患儿退出原因与性别、农村人口、疗效不好有关;(4)在发作类型中婴儿痉挛症、肌阵挛发作者更易出现脱落。结论 :对儿童癫痫的诊断、分型应尽可能准确,掌握好德巴金缓释片治疗的指针;用药前充分与患儿家长沟通,向患儿及其家长充分宣教癫痫的有关知识 ,取得其对德巴金缓释片的了解并加强用药期间各种形式的随访是目前减少治疗脱落的有效措施。

Objective:To explore the causes of withdrawal of the Depakine Cheono(DK)therapy for treating pediatric epilepsy.Methods:Adopt Multinomial Regression Logistic Analysis on the withdrawal of Depakine Chrono therapy in34cases upon investigation on87children reˉceiving the treatment in the open label experiment conducted in our hospital.Results:(1)Those children who chose to withdraw account for39.08%of the total(34/87),while74.18%of them keep on receiving the treatment.(2)The common ill effect includes hypohepatia,lose one's hair,decrease of platelet and behavior disorder.(3)It's found that the withdrawal of DKrelates with some factors including sex,rural population and unsatisfying effect.(4)The withdrawal is more frequently found among those children with infantile Spasms and Myoclonic Seizure.Conclusion The diagnosis and typing on pediatric epilepsy should be as accurate as possible.For preventing the patients from withdrawing,to fully control the DK treatment and communicate with the patients before treating as well as conduct timely followup can be regarded as the effective measures at present.