中山市三乡镇幼儿园新生乙型肝炎疫苗接种率与HbsAg阳性率关系调查分析

The investigation and analysis of the relationship between inoculation rate of hepatitis B vaccine and HBsAg positive rate in infant school of Sanxiang town in Zhongshan

目的 :为了解学龄前儿童乙型肝炎疫苗接种率与HbsAg阳性率关系状况。方法 :从2000～2003年每年对所有新入中山市三乡镇各幼儿园的儿童调查乙型肝炎疫苗接种史和用ELISA方法检测HbsAg。结果 :2000～2003年共调查2663名儿童 ,乙型肝炎疫苗接种率为88.32 % ,2000年与2002、2003年的接种率差异有显著性 (x2=4.89、6.92 ,P均<0.05)。HbsAg阳性率为1.01 % ,2000～2003年HbsAg阳性率差异无显著性(x2=4.47,P>0.05) ,有乙肝疫苗接种史和无接种史的HbsAg阳性率分别为0.34 % ,6.11 % ,其差异有非常显著性 (x2=91.09 ,P<0.005)。结论 :乙肝疫苗接种率的提高 ,能有效阻断HbsAg的传播 ,该区域学龄前期儿童HbsAg阳性率处于较低水平。

Objective:To investigate the relationship between inoculation rate of hepatitis B vaccine and hepatitis B surface antigen(HBsAg)positive rate in preschool children.Methods:HBsAg in2663infants taken to each infant school of Sanxiang town in Zhongshan from2000to2003was detected by enzyme linked immunosorbent assay(ELISA)method,and the inoculation history of hepatitis B vaccine was investigated.Results:The inoculation rate of hepatitis B vaccine was88.12%.Compared2000with2002and2003,the difference of the inoculation rate of hepatitis B vaccine was statistically significant(x 2 =4.89,all,P<0.05).The HBsAg positive rate was1.01%,the difference of the HBsAg positive rate was not statistically significant during2000～2003(x 20.05,3 =4.47,P>0.05).The HBsAg positive rate was0.34%in patients with inoculation history of hepatitis B vaccine and6.11%in patients without inoculation history of hepatitis B vaccine,with a significant statistical difference between them(x 2 =91.09,P<0.05).Conclusion:The increase of the inoculation rate of hepatitis B vaccine can effectively block the spread of HBsAg.The HBsAg positive rate of the prschool children is on a lower level.