腹膜小细胞型恶性间皮瘤的临床病理特点

Cinicopathological features of small cell malignant mesothelioma in peritoneum

目的 探讨腹膜小细胞型恶性间皮瘤的临床与病理特征。方法 对9例腹膜小细胞型恶性间皮瘤进行临床、病理形态学、免疫组化、组织化学及电镜观察,并结合文献探讨其临床表现和病理诊断。结果 9例中男性6例,女性3例,平均年龄58岁,主要症状为腹部疼痛或不适。肿瘤细胞CK、vimentin及抗间皮细胞抗原均呈阳性表达;CI染色均有不同程度阳性改变,而HCI染色则阴性。7例电镜见瘤细胞表面少数细长微绒毛,并见张力微丝及较多桥粒。结论 结合临床表现,采用光镜、电镜、组织化学及免疫组化等方法能够明确诊断腹膜小细胞型恶性间皮瘤。

Objective To investigate the clinical and pathological characteristics of small cell malignant mesothelioma of the peritoneum (SCMMP). Methodls Nine cases of SCMMP were analyzed by light, histochemical and immunohistochemical stains and electron microscopic observation, and the clinical and pathological features were reviewed with related literature. Results Of 9 cases, 6 cases were male and 3 cases were female with a mean age of 58 years old. The major symptoms were abdominal pain or discomfortable. Immunohistochemical staining showed that the neoplastic cells of all cases were positive for CK, vimentin, anti-mesothelial cell antigen and CI but negative for HCI. Electron microscopic study of 7 cases showed that the neoplastic cells had a few slender microvilli in cell surface, microfilament (tono-filament) and more desmosomes. Conclusion The diagnosis of SCMMP can be established with the combination of clinical manifestation, light and electron microscopic observations and immunohistochemical stains.