264例先天性畸形围产儿尸检病理分析

Pathological features of congenital malformation: an analysis of 264 autopsy cases

目的 探讨高原地区围产儿先天性畸形的临床病理特点及发病原因。方法 通过对264例先天性畸形死亡围产儿进行尸体解剖及病理诊断,确诊各种先天性畸形。结果 发现单纯内脏畸形114例,单纯体表畸形85例,体表合并内脏畸形65例。各系统发生畸形的构成比例依次为心血管系统、中枢神经系统、消化系统、呼吸系统及泌尿生殖系统。结论 围产儿先天性畸形发生率高与地处高原有关。

Objective To study the clinical and pathological features and cause of the congenital malformation in perinatal infants at high attitude areas. Methods A total of 264 cases of the congenital malformation in perinatal infants were confimed by gross examination and light microscopy. Results The results showed 114 cases with malformation in body surfaces, 85 cases with visceral malformations, and 65 cases with both. Incidences of the malformations were high in cardiovascular system, central nervous system, digestive system, respiratory system and genitourinary system in turn. Conclusion High incidence of congenital malfo-mations in perinatal infants may be related to the geographic features of high attitude areas.