血浆中性粒细胞弹性蛋白酶与冠心病的关系

Plasma neutrophil elastase conce tration in of patients with coronary heart disease

目的 :探讨血浆中性粒细胞弹性蛋白酶 (neutrophilelastase,NE)与冠心病 (CHD)的关系。方法 :对85例观察对象进行分组 ,根据冠状动脉造影结果分为 :简单病变组 2 4例 ,复杂病变组 5 1例 ,正常对照组 10例。根据CHD病情分为 :急性心肌梗死 (AMI)组 9例 ,不稳定型心绞痛 (UAP)组 4 5例 ,稳定型心绞痛 (SAP)组 2 1例 ,正常对照组 10例。用酶联免疫吸附法 (ELASA)检测血浆NE含量 ,比较不同组间NE含量。结果 :血浆NE含量 :复杂病变组 [(6 3.4 2± 13.6 2 ) μg/L]高于简单病变组 [(4 4 .5 0± 12 .73) μg/L],差异有统计学意义 (P <0 .0 1)。AMI组 [(71.4 8± 10 .16 ) μg/L]高于UAP组 [(6 1.2 7± 14 .5 7) μg/L],但差异无统计学意义 (P >0 .0 5 ) ,明显高于SAP组 [(4 0 .95± 10 .0 9) μg/L]及正常对照组 [(36 .6 3± 12 .35 ) μg/L],差异均有统计学意义 (P <0 .0 1) ,后两组间比较差异无统计学意义 (P >0 .0 5 )。UAP组明显高于SAP组及正常对照组 ,差异有统计学意义 (P <0 .0 1)。结论 :血浆NE含量与冠状动脉病变稳定性及CHD病情严重性相关 ,NE可能是冠状动脉病变活动性的标志物。

Objective:To investigate the correlation between plasma neutrophil elastase concentration the stability of coronary lesions in patients with CHD. Method:Eighty-five subjects were divided into groups, according to coronary angiography and clinical manifestation, including 24 with sample lesioos , 51 with complex lesions, 9 acute myocardial infarction(AMI), 45 unstable angina pectoris(UAP), 21 stable angina pectoris (SAP) and 10 normal healthy control subjects. Plasma neutrophil elastase(NE) concentrations were determined by ELASA and then they were compared between the groups. Result:Plasma concentrations of NE were greater in patients with complex lesion ( 63.42± 13.62)μg/L than in those with simple elision ( 44.50± 12.73)μg/L (P< 0.05 ) and greater in AMI group ( 71.48± 10.16)μg/L than in the UAP group ( 61.27± 14.57)μg/L (P> 0.05), the SAP group ( 40.95± 10.09)μg/L (P< 0.01)and normal healthy control group ( 36.63± 12.35)μg/L (P< 0.01).It was greater in UAP group than in SAP group (P< 0.01) and in normal healthy control group (P< 0.01). Conclusion:Plasma neutrophil elastase concentrations are related with the stability of coronary lesions as well as the severity of CHD. NE may be a market of coronary disease activity.