摘要
应用RP-HPLC法测定吡喹酮及其脂质体在小鼠体内的分布。用外标定量法测定各组织中的含量,其回收率在96.46～103.13%之间,变异系数小于2.95%。实验结果表明,吡喹酮脂质体较游离吡喹酮在小鼠肝、脾组织内药物总含量明显增高,半衰期延长。
The distribution in mouse of praziquantel and it's liposome has been studied by the auth-ors using RP-HPLC. Drug concentration in organs can thus be determined by using externalstandard with a recovery range of 96. 46～103. 13% and a coefficient of variation<2. 95×10^(-2).The results indicated that the livers and spleens level of the liposome are higher than thoseof the praziquantel, and that the t_(1/2) of the former is prolonged.
出处
《分析测试学报》
CAS
CSCD
1993年第1期48-50,共3页
Journal of Instrumental Analysis
关键词
吡喹酮
脂质体
高效液相色谱
Praziquantel
Liposome
RP-HPLC
Hydatid disease
