鸡的7种细胞因子的一些分子生物学特性

Biological Characteristics of Seven Chicken Cytokines

细胞因子是免疫系统的重要调节因子 ,能够影响免疫应答的类型和水平。近年来 ,禽细胞因子研究取得很大进展 ,随着更多鸡细胞因子基因的发现及其生物学特性的研究 ,临床应用细胞因子成为可能。文章对 7种鸡细胞因子——干扰素 (I型和 II型 ) ,白细胞介素 (IL-2、IL-6、IL-1 5和 IL-1 8)和鸡髓细胞生长因子(c MGF)一些生物学特性作了综述 ,主要包括c DNA克隆的方法、c DNA及其编码蛋白的生物学特性、检测方法、主要生物学功能 ,并与相应的哺乳动物细胞因子比较 ,阐明鸡的细胞因子与哺乳动物的异同点。

Cytokines, as central regulators of the immune system, can regulate the type and level of immune responses. While more and more avian cytokines are cloned in recent years, work on their potential use is initiated as immune response modifiers to stimulate innate immunity or as immune adjuvants to enhance the efficacy of vaccines.This paper reviewed recent work on biological characteristics of chicken interferon-α/βand IFN-γ,several interleukins(IL-1,IL-2,IL-6,IL-15,IL-18) and chicken myelomonocytic growth factor(cMGF).