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鸡白细胞介素15的研究进展

Advances in Chicken Interleukin-15
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摘要 白细胞介素 1 5(IL -1 5)是 1 994年发现的一种能促进细胞生长和分化的细胞因子 ,主要由天然免疫细胞产生。鸡 IL-1 5是一种新发现的且与 IL-2活性相似的细胞因子 ,它作为疫苗佐剂研究的重要候选细胞因子有巨大潜力。文章主要围绕鸡 IL-1 5的发现、基因及蛋白结构、受体及生物学特性等作了综述。 Interleukin-15 (IL-15) is a multifunctional cytokine that plays a major role in promoting cell growth and differentiation. IL-15 is produced mainly by natural immunocyte.Recent results have shown that chicken cytokines share similar biological activity with mammalian cytokines, especially, in immunological enhancement of IL-2 and IFN-γ. Chicken interleukin-15, Which was discovered in 2001, plays a main role in activating NK cells and CD8+ memory T cells, and may therefore have potential as a vaccine adjuvant.This review will focus on the recent advances in chicken interleukin-15.
作者 独军政 刘胜旺 陈怀涛 孔宪刚
机构地区 中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室 甘肃农业大学动物医学院
出处 《动物医学进展》 CSCD 2004年第4期59-62,共4页 Progress In Veterinary Medicine
基金 国家高技术研究发展计划 (86 3计划 )资助项目 (2 0 0 1AA2 4 90 0 32 )
关键词 鸡 白细胞介素15 细胞因子 疫苗佐剂 基因 蛋白结构 受体 生物学特性 chicken interleukin-15 molecular characteristic receptor biological activity
分类号 S858.31 [农业科学—临床兽医学] S852.42 [农业科学—基础兽医学]
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动物医学进展
2004年 第4期

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