摘要
为了研究亚硒酸钠对小鼠胸腺、脾脏组织结构的影响。给小鼠腹腔内注射 0 .5%半乳糖(50 mg/ kg/ d) ,连续 8周 ,建立衰老模型组 ;自第 4周开始给衰老用药组腹腔注射亚硒酸钠(2 mg/ kg/ d) ,连续 4周。应用电子天平称量小鼠脾、胸腺重量 ,并对胸腺、脾进行常规石蜡切片 ,观察衰老模型组、衰老用药组和对照组之间胸腺、脾组织结构的差异。结果表明 ,硒对老龄小鼠胸腺、脾的重量影响不大 ,组织切片观察显示 ,亚硒酸钠有延缓小鼠脾脏、胸腺组织衰老的作用 。
To study effects of selenium(Se) on histological structure of the immune organ in rats.Methods: Km rats were given intraabdominal injection of D-Galactose(50 mg/kg) once a day for 8 weeks. After 4 weeks a group of Km rats were given intraabdominal injection of Se(2 mg/kg) at same time. with the electronic-weighting system and the technique of histological section observed if injecting of Se made weight and structure changes on the rats' spleen and thymus. Result:The weight of the thymus and spleen were not changed.but the involution rats' thymic lobules were quite distinct. Se could delay course of senility of rats' spleen and thymus.
出处
《动物医学进展》
CSCD
2004年第4期94-96,共3页
Progress In Veterinary Medicine