^(59)Fe在幼龄大鼠体内的滞留、分布及内照射剂量特点

SOME CHARACTERISTIC OF THE RETENTION,DISTRIBUTION AND INTERNAL DOSES OF ^(59)Fe IN RATS

经胃灌入后,^(59)Fe在大鼠内的整体滞留,能很好地拟合二项指数方程。幼年组与成年组的慢组分生物半排期,分别为95d及109d,无统计学显著性差别。^(59)Fe的主要分布器官是肝与骨髓。^(59)Fe在器官中的滞留方程为一项或二项指数式。在幼年组多数器官中,^(59)Fe排出比成年组快。幼年组的剂量特点是多数器官总累积剂量较大,剂量累积速度较快。口服同量的^(59)Fe,对幼年鼠有较大生物效应。

After gastric intubation, the whole body ^(59)Fe-retentions in rats were fit to two compartment exponential equations. The biological half lifes for ^(59)Fein the slow compartment are 95 and 109 days for young and adult rats respectively,not statistically significantly different. The main ^(59)Fe-acculative organs are liver andbone marrow. The biological eliminations of ^(59)Fe from most organs in young ratsare faster than in adult rats. The young rats get more total accumulative dose in organs except liver and total body and have a faster dose accumulative speed thanthe adult rats. Equal quantities of ^(59)Fe P. O. may probably give young rats moreintensive biological effects than adult rats.