造血干细胞自我更新调控及wnt信号在其中的作用

Regulation of Haematopoietic Stem Cells Self-renenwal and The Role of wnt Signaling in The Process

干细胞生物学最为重要的问题之一就是干细胞自我更新的调控机制 .造血干细胞具有自我更新和分化为各血细胞世系的能力 ,但目前对其自我更新的调控机制尚未明确 .大量的研究表明 ,造血干细胞的自我更新受到来自其所处微环境和自身内在基因的共同调控 .经典的发育调控通路———wnt信号通路在造血干细胞自我更新调控中起着至关重要的作用 .就造血干细胞自我更新及其调控 ,特别是wnt信号通路在其中的作用作一综述 ,并对其应用前景和今后的研究方向作了展望 .

The mechanisms of regulating stem cells self-renewal is one of the most important issues in stem cell biology. Haematopoietic stem cells (HSCs) have the ability to renew themselves and to differentiate into all lineages of the blood but, the mechanism that control HSCs self-renewal remain unclear. Most researches showed it was controled by the signal and growth factors from the microenvironment and the cell-autonomous components. The writ signaling pathway plays an important role in this process. The HSCs self-renewal, the mechanism, the role of wnt signaling pathway and the perspectives of application and research in this field are discussed.