组织转谷氨酰胺酶与神经退行性疾病

The Role of Tissue Transglutaminase in Neurodegenerative Diseases

组织转谷氨酰胺酶(tissue transglutaminase,tTG)广泛分布于各种组织及细胞中,是一个多功能蛋白质。tTG能催化Ca2+依赖的蛋白质交联反应,并在多种生物学过程中起到了重要作用,如细胞生长与分化、受体介导的胞吞作用、细胞黏附、细胞形态的维持以及细胞凋亡等。已有研究表明,tTG可能在多种神经退行性疾病的病理生理过程中起到了重要作用。现就近年来有关tTG与神经退行性疾病研究的一些进展做一介绍。

Tissue transglutaminase (tTG) is one of members of transglutaminase family. It is believed to be a multifunctional protein, which can catalyze cross-linking of protein and hydrolyzation of GTP and ATP. Furthermore, tTG can function as Gαh in Ca2+-associated signal pathway. It has been reported that tTG is involved in a broad range of biological processes such as cell growth and differentiation, receptor-mediated endocytosis, cell adhesion, maintenance of cell morphology and inducement of apoptosis. Recently, it has been suggested that tTG may play important roles in pathogenesis of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease. Some recent progress on the involvement of tTG in these diseases will be presented in this review.