CD4^+T细胞分化与表观遗传作用

The Relationships between CD4^+T Cell Differentiation and Epigenetic Regulation

DNA甲基化、染色质重塑等表观遗传作用对CD4+T细胞向Th1和Th2的分化有重要的影响,现对Th1细胞表达IFN-γ以及Th2细胞表达IL-4／IL-13在基因转录水平的调节作用给予概述,重点阐述相关转录因子、酶以及蛋白质复合物所发挥的表观遗传调节作用的可能机制。

The epigenetic regulation, such as genomic methylation, chromatin remodeling or histone deacetylation, has great influence on the maturation of CD4+T helper cells into Th1 phenotype or Th2 phenotype. In this paper, epigenetic regulation of IFN-γ and IL-4/IL-13 loci in Th1/Th2 cells has been reviewed in some detail. It will help to understand the possible role of the correlated transcription factors, enzymes or multiprotein complex in this epigenetic regulation.