同源异型盒基因对血管平滑肌细胞的调控作用

Regulation of Vascular Smooth Muscle Cell by Homeobox Gene

同源异型盒基因是一类对生物体的生长、发育和分化从时间和空间上进行协调的调控基因。构成血管中膜的血管平滑肌细胞表型具有极大的可塑性。在一些病理性血管重构时,血管平滑肌细胞可发生表型调变,从分化型调变为去分化型,具备增殖和迁移能力。在此过程中,多种同源异型盒基因的表达发挥了重要的调控作用。现就同源异型盒基因与血管平滑肌细胞的表型调变、增殖和迁移的关系等方面的研究进展作一综述。

Homeobox genes are critical in the regulation of cell proliferation, differentiation and migration. Vascular smooth muscle cells occur phenotypic modulation during the pathological processes such as atherosclerosis and arterial restenosis after balloon angioplasty. Recently, homeobox genes have been detected in vascular smooth muscle cells, and may play an important role in regulating these processes. This paper will review the homeobox genes involve in the phenotypic modulation, proliferation and migration of vascular smooth muscle cells.