核内不均一核糖核蛋白在前体mRNA加工中的功能

The Function of Heterogeneous Nuclear Ribonucleoproteins in pre-mRNA Processing

核内不均一核糖核蛋白(hnRNP)是一类存在于真核生物体内具有类似结构特征的高丰度RNA结合蛋白,一般均匀分布在核内。多种hnRNP具有多样的功能,参与从转录调节,前体mRNA剪接,mRNA输出到mRNA降解等多种生物过程,从而进行基因表达调控。现着重介绍hnRNP在前体mRNA加工过程(加帽,剪接,加尾,输出,选择性降解)中的功能及研究进展。

Heterogeneous nuclear ribonucleoprotein (hnRNP) is a family of proteins that are highly expressed in eukaryotic cells and diffusely distributed in the nucleus. Various hnRNP proteins share similar structural characteristics and play a variety of functions in regulation of gene expression, including transcription, pre-mRNA splicing, mRNA export and mRNA decay. In this review, we briefly summarize the recent progresses regarding the function of hnRNP in pre-mRNA processing.