肿瘤治疗中的多细胞耐受性与三维细胞培养

Multicellular Resistance in Cancer Therapy and Three-dimensional Cell Culture

肿瘤治疗中的多细胞耐受性是由于体内肿瘤具有三维结构而产生的对药物、射线等作用的耐受性。近年来人们利用体外三维细胞培养技术研究多细胞耐受性,发现其机制主要为三维结构相关的耐受性和接触性耐受性,并发现一些逆转或减弱多细胞耐受性的方法,显示了其作为临床肿瘤单独治疗或联合治疗的应用前景。

Multicellular resistance (MCR) phenomenon in cancer treatment is due to there is the three-dimensional structure for tumor inside the body. In recent years, MCR phenomenon has been studied by using three-dimensional cell culture technology in vitro. It was found that the mechanism of MCR is mainly related to three-dimensional structure itself, i.e. intrinsic resistance and contact resistance. In addition, some methods were found to be able to reverse or decrease MCR, which might be used in cancer treatment by oneself or united with others in the future.